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Terrence A. Barrett, MD
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  • Connect
  • About
  • Education
  • Publications
  • t.barrett@uky.edu
  • Clinic : (859) 323-0079; Academic Office: (859) 323-4887
  • MN649 WM R WILLARD MED ED BLDG
Position(s): 
Professor
Division Chief
Affiliation(s): 
Internal Medicine
Other Affiliation(s): 
Internal Medicine - Digestive Health
Microbiology, Immunology & Molecular Genetics - Adjunct Faculty
Bio / Education: 
University of Illinois, Chicago, ILMD06/1983Medicine
Rush Presbyterian St. Luke's Hospital, Chicago, ILResidency06/1986Internal Medicine
University of Chicago, Chicago, ILFellowship06/1990Gastroenterology
PubMed Publications: 
  • Wechsler, JB ;Szabo, A.;Hsu, CL ;Krier-Burris, RA ;Schroeder, HA ;Wang, MY ;Carter, RG ;Velez, TE ;Aguiniga, LM ;Brown, JB ;Miller, ML ;Wershil, BK ;Barrett, TA ;Bryce, PJ "Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis." Mucosal immunology 11, 3 (2018): 861-870. [PubMed Link] | [ Full text ]
  • Goretsky, T.;Bradford, EM ;Ye, Q.;Lamping, OF ;Vanagunas, T.;Moyer, MP ;Keller, PC ;Sinh, P.;Llovet, JM ;Gao, T.;She, QB ;Li, L.;Barrett, TA "Beta-catenin cleavage enhances transcriptional activation." Scientific reports 8, 1 (2018): 671. [PubMed Link] | [ Full text ]
  • Davoudi, Z.;Peroutka-Bigus, N.;Bellaire, B.;Wannemuehler, M.;Barrett, TA ;Narasimhan, B.;Wang, Q. "Intestinal organoids containing poly(lactic-co-glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases." Journal of biomedical materials research. Part A 106, 4 (2018): 876-886. [PubMed Link] | [ Full text ]
  • Cai, T.;Qi, Y.;Jergens, A.;Wannemuehler, M.;Barrett, TA ;Wang, Q. "Effects of six common dietary nutrients on murine intestinal organoid growth." PloS one 13, 2 (2018): e0191517. [PubMed Link] | [ Full text ]
  • Bradford, EM ;Ryu, SH ;Singh, AP ;Lee, G.;Goretsky, T.;Sinh, P.;Williams, DB ;Cloud, AL ;Gounaris, E.;Patel, V.;Lamping, OF ;Lynch, EB ;Moyer, MP ;De Plaen, IG ;Shealy, DJ ;Yang, GY ;Barrett, TA "Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease." Journal of immunology (Baltimore, Md. : 1950) 199, 5 (2017): 1886-1897. [PubMed Link] | [ Full text ]
  • Feng, Y.;Demehri, FR ;Xiao, W.;Tsai, YH ;Jones, JC ;Brindley, CD ;Threadgill, DW ;Holst, JJ ;Hartmann, B.;Barrett, TA ;Teitelbaum, DH ;Dempsey, PJ "Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition." Cellular and molecular gastroenterology and hepatology 3, 3 (2017): 447-468. [PubMed Link] | [ Full text ]
  • Pauly, NJ ;Michailidis, L.;Kindred, MG ;Flomenhoft, D.;Lofwall, MR ;Walsh, SL ;Talbert, JC ;Barrett, TA "Predictors of Chronic Opioid Use in Newly Diagnosed Crohn's Disease." Inflammatory bowel diseases 23, 6 (2017): 1004-1010. [PubMed Link] | [ Full text ]
  • Bradford, EM ;Thompson, CA ;Goretsky, T.;Yang, GY ;Rodriguez, LM ;Li, L.;Barrett, TA "Myo-inositol reduces β-catenin activation in colitis." World journal of gastroenterology 23, 28 (2017): 5115-5126. [PubMed Link] | [ Full text ]
  • Cohran, V.;Managlia, E.;Bradford, EM ;Goretsky, T.;Li, T.;Katzman, RB ;Cheresh, P.;Brown, JB ;Hawkins, J.;Liu, SXL ;De Plaen, IG ;Weitkamp, JH ;Helmrath, M.;Zhang, Z.;Barrett, TA "Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection." The American journal of pathology 186, 7 (2016): 1837-1846. [PubMed Link] | [ Full text ]
  • Goretsky, T.;Bradford, EM ;Ryu, H ;Tahir, M.;Moyer, MP ;Gao, T.;Li, L.;Barrett, TA "A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer." The Journal of biological chemistry 291, 8 (2016): 4166-77. [PubMed Link] | [ Full text ]
  • Gounaris, E.;Ishihara, Y.;Shrivastrav, M.;Bentrem, D.;Barrett, TA "Near-Infrared Fluorescence Endoscopy to Detect Dysplastic Lesions in the Mouse Colon." Methods in molecular biology (Clifton, N.J.) 1422, (2016): 137-47. [PubMed Link] | [ Full text ]
  • Wen, YA ;Li, X.;Goretsky, T.;Weiss, HL ;Barrett, TA ;Gao, T. "Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis." Biochimica et biophysica acta 1852, 10 Pt A (2015): 2013-23. [PubMed Link] | [ Full text ]
  • Mathew, JM ;Tryphonopoulos, P.;DeFaria, W.;Ruiz, P.;Miller, J.;Barrett, TA ;Tzakis, AG ;Kato, T. "Role of innate and acquired immune mechanisms in clinical intestinal transplant rejection." Transplantation 99, 6 (2015): 1273-81. [PubMed Link] | [ Full text ]
  • Wang, Y.;Liu, X.;Pijut, SS ;Li, J.;Horn, J.;Bradford, EM ;Leggas, M.;Barrett, TA ;Graf, GA "The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination." Journal of lipid research 56, 4 (2015): 810-20. [PubMed Link] | [ Full text ]
  • Managlia, E.;Katzman, RB ;Brown, JB ;Barrett, TA "Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells." Inflammatory bowel diseases 19, 10 (2013): 2051-60. [PubMed Link] |
  • Gounaris, E.;Martin, J.;Ishihara, Y.;Khan, MW ;Lee, G.;Sinh, P.;Chen, EZ ;Angarone, M.;Weissleder, R.;Khazaie, K.;Barrett, TA "Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis." Inflammatory bowel diseases 19, 7 (2013): 1339-45. [PubMed Link] |
  • Barrett, TA "Developmental biology. Intestinal wound healing requires a Wnt balancing act." Science (New York, N.Y.) 338, 6103 (2012): 51-2. [PubMed Link] | [ Full text ]
  • Goretsky, T.;Dirisina, R.;Sinh, P.;Mittal, N.;Managlia, E.;Williams, DB ;Posca, D.;Ryu, H ;Katzman, RB ;Barrett, TA "p53 mediates TNF-induced epithelial cell apoptosis in IBD." The American journal of pathology 181, 4 (2012): 1306-15. [PubMed Link] | [ Full text ]
  • Dirisina, R.;Katzman, RB ;Goretsky, T.;Managlia, E.;Mittal, N.;Williams, DB ;Qiu, W.;Yu, J.;Chandel, NS ;Zhang, L.;Barrett, TA "p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis." Gastroenterology 141, 3 (2011): 1036-45. [PubMed Link] | [ Full text ]
  • Lee, G.;Goretsky, T.;Managlia, E.;Dirisina, R.;Singh, AP ;Brown, JB ;May, R.;Yang, GY ;Ragheb, JW ;Evers, BM ;Weber, CR ;Turner, JR ;He, XC ;Katzman, RB ;Li, L.;Barrett, TA "Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis." Gastroenterology 139, 3 (2010): 869-81, 881.e1-9. [PubMed Link] | [ Full text ]
  • Tang, Y.;Clayburgh, DR ;Mittal, N.;Goretsky, T.;Dirisina, R.;Zhang, Z.;Kron, M.;Ivancic, D.;Katzman, RB ;Grimm, G.;Lee, G.;Fryer, J.;Nusrat, A.;Turner, JR ;Barrett, TA "Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation." The American journal of pathology 176, 1 (2010): 158-67. [PubMed Link] | [ Full text ]
  • Brown, JB ;Lee, G.;Managlia, E.;Grimm, GR ;Dirisina, R.;Goretsky, T.;Cheresh, P.;Blatner, NR ;Khazaie, K.;Yang, GY ;Li, L.;Barrett, TA "Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis." Gastroenterology 138, 2 (2010): 595-605, 605.e1-3. [PubMed Link] | [ Full text ]
  • He, XC ;Yin, T.;Grindley, JC ;Tian, Q.;Sato, T.;Tao, WA ;Dirisina, R.;Porter-Westpfahl, KS ;Hembree, M.;Johnson, T.;Wiedemann, LM ;Barrett, TA ;Hood, L.;Wu, H.;Li, L. "PTEN-deficient intestinal stem cells initiate intestinal polyposis." Nature genetics 39, 2 (2007): 189-98. [PubMed Link] | [ Full text ]
  • Sanft, T.;Barrett, TA ;Barr, WG ;Jones, MP "Henoch-Schönlein Purpura Presenting as Terminal Ileitis: Case Report and Review of Unusual Causes of Ileitis." Gastroenterology & hepatology 2, 5 (2006): 375-378. [PubMed Link] |
  • Zhang, Z.;Kaptanoglu, L.;Tang, Y.;Ivancic, D.;Rao, SM ;Luster, A.;Barrett, TA ;Fryer, J. "IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection." Gastroenterology 126, 3 (2004): 809-18. [PubMed Link] | [ Full text ]
  • Hurst, SD ;Barrett, TA "T-cell responses to enteric antigens." Seminars in gastrointestinal disease 7, 3 (1996): 118-23. [PubMed Link] |
Chairman’s Office: (859) 257-5116
Clinical Questions: (859) 257-1000
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