Terrence A. Barrett, M.D.

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About
Education
Publications

t.barrett@uky.edu

Clinic : (859) 323-0079
Academic Office: (859) 323-4887

Office: MN 649 Medical Science Bldg.

Position(s):

Professor

Chief, Division of Digestive Diseases and Nutrition

Affiliation(s):

Internal Medicine

Other Affiliation(s):

Internal Medicine - Digestive Health

Microbiology, Immunology & Molecular Genetics - Adjunct Faculty

Bio / Education:

University of Illinois, Chicago, IL	MD	06/1983	Medicine
Rush Presbyterian St. Luke's Hospital, Chicago, IL	Residency	06/1986	Internal Medicine
University of Chicago, Chicago, IL	Fellowship	06/1990	Gastroenterology

PubMed Publications:

Perry, C ; Kapur, N ; Barrett, TA "DPP-4 as a Novel Biomarker for Inflammatory Bowel Disease: Is It Ready for Clinical Use?" Inflammatory bowel diseases 26, 11 (2020): 1720-1721. [PubMed Link] | [ Full text ]
Ali, N.; Nguyen, CB ; Chandrakesan, P ; Wolf, RF ; Qu, D.; May, R.; Goretsky, T.; Fazili, J ; Barrett, TA ; Li, M.; Huycke, MM ; Bronze, MS ; Houchen, CW "Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism." Scientific reports 10, 1 (2020): 10578. [PubMed Link] | [ Full text ]
Elmoursi, A ; Barrett, TA ; Perry, C "Double Biologic Therapy for Refractory Stricturing Crohn's Disease: A Successful Case of Deep Remission with Ustekinumab and Vedolizumab." Inflammatory bowel diseases 26, 7 (2020): e62-e63. [PubMed Link] | [ Full text ]
Perry, C ; Fischer, K.; Elmoursi, A ; Kern, C ; Currier, A ; Kudaravalli, P ; Akanbi, O ; Tripathi, N ; Yarra, P ; Su, L.; Flomenhoft, D.; Stromberg, A.; Barrett, TA "Vedolizumab Dose Escalation Improves Therapeutic Response in a Subset of Patients with Ulcerative Colitis." Digestive diseases and sciences (2020): [PubMed Link] | [ Full text ]
Barrett, TA "Outpatient Cardiac Palliative Care Reduces Healthcare Utilization." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 39, 4S (2020): S362. [PubMed Link] | [ Full text ]
Li, C.; Zhou, Y.; Rychahou, P.; Weiss, HL ; Lee, EY ; Perry, CL ; Barrett, TA ; Wang, Q.; Evers, BM "SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation." Cellular and molecular gastroenterology and hepatology 10, 1 (2020): 43-57. [PubMed Link] | [ Full text ]
Haider, SA ; Yadav, A.; Perry, C ; Su, L.; Akanbi, O ; Kudaravalli, P ; Tripathi, N ; Hashim, MA ; Abdelsalam, M ; Hussein, M.; Elkheshen, A ; Patel, V.; Ali, SE ; Lamb, L ; Ingram, K ; Mayne, C ; Stuffelbeam, AB ; Flomenhoft, D.; Stromberg, A.; Barrett, TA "Ustekinumab dose escalation improves clinical responses in refractory Crohn's disease." Therapeutic advances in gastroenterology 13, (2020): 1756284820959245. [PubMed Link] | [ Full text ]
Qi, Y.; Lohman, J ; Bratlie, KM ; Peroutka-Bigus, N.; Bellaire, B.; Wannemuehler, M.; Yoon, KJ ; Barrett, TA ; Wang, Q. "Vitamin C and B<sub>3</sub> as new biomaterials to alter intestinal stem cells." Journal of biomedical materials research. Part A 107, 9 (2019): 1886-1897. [PubMed Link] | [ Full text ]
Wen, YA ; Xiong, X.; Scott, T.; Li, AT ; Wang, C.; Weiss, HL ; Tan, L.; Bradford, E ; Fan, TWM ; Chandel, NS ; Barrett, TA ; Gao, T. "The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer." Cell death and differentiation 26, 10 (2019): 1955-1969. [PubMed Link] | [ Full text ]
Managlia, E.; Liu, SXL ; Yan, X.; Tan, XD ; Chou, PM ; Barrett, TA ; De Plaen, IG "Blocking NF-κB Activation in Ly6c<sup>+</sup> Monocytes Attenuates Necrotizing Enterocolitis." The American journal of pathology 189, 3 (2019): 604-618. [PubMed Link] | [ Full text ]
Shrivastav, M ; Gounaris, E.; Khan, MW ; Ko, J.; Ryu, SH ; Bogyo, M ; Larson, A ; Barrett, TA ; Bentrem, DJ "Correction: Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope." PloS one 14, 1 (2019): e0210677. [PubMed Link] | [ Full text ]
Wechsler, JB ; Szabo, A.; Hsu, CL ; Krier-Burris, RA ; Schroeder, HA ; Wang, MY ; Carter, RG ; Velez, TE ; Aguiniga, LM ; Brown, JB ; Miller, ML ; Wershil, BK ; Barrett, TA ; Bryce, PJ "Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis." Mucosal immunology 11, 3 (2018): 861-870. [PubMed Link] | [ Full text ]
Goretsky, T.; Bradford, EM ; Ye, Q.; Lamping, OF ; Vanagunas, T.; Moyer, MP ; Keller, PC ; Sinh, P.; Llovet, JM ; Gao, T.; She, QB ; Li, L.; Barrett, TA "Beta-catenin cleavage enhances transcriptional activation." Scientific reports 8, 1 (2018): 671. [PubMed Link] | [ Full text ]
Davoudi, Z.; Peroutka-Bigus, N.; Bellaire, B.; Wannemuehler, M.; Barrett, TA ; Narasimhan, B.; Wang, Q. "Intestinal organoids containing poly(lactic-co-glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases." Journal of biomedical materials research. Part A 106, 4 (2018): 876-886. [PubMed Link] | [ Full text ]
Cai, T.; Qi, Y.; Jergens, A.; Wannemuehler, M.; Barrett, TA ; Wang, Q. "Effects of six common dietary nutrients on murine intestinal organoid growth." PloS one 13, 2 (2018): e0191517. [PubMed Link] | [ Full text ]
Bradford, EM ; Ryu, SH ; Singh, AP ; Lee, G.; Goretsky, T.; Sinh, P.; Williams, DB ; Cloud, AL ; Gounaris, E.; Patel, V.; Lamping, OF ; Lynch, EB ; Moyer, MP ; De Plaen, IG ; Shealy, DJ ; Yang, GY ; Barrett, TA "Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease." Journal of immunology (Baltimore, Md. : 1950) 199, 5 (2017): 1886-1897. [PubMed Link] | [ Full text ]
Feng, Y.; Demehri, FR ; Xiao, W.; Tsai, YH ; Jones, JC ; Brindley, CD ; Threadgill, DW ; Holst, JJ ; Hartmann, B.; Barrett, TA ; Teitelbaum, DH ; Dempsey, PJ "Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition." Cellular and molecular gastroenterology and hepatology 3, 3 (2017): 447-468. [PubMed Link] | [ Full text ]
Pauly, NJ ; Michailidis, L.; Kindred, MG ; Flomenhoft, D.; Lofwall, MR ; Walsh, SL ; Talbert, JC ; Barrett, TA "Predictors of Chronic Opioid Use in Newly Diagnosed Crohn's Disease." Inflammatory bowel diseases 23, 6 (2017): 1004-1010. [PubMed Link] | [ Full text ]
Bradford, EM ; Thompson, CA ; Goretsky, T.; Yang, GY ; Rodriguez, LM ; Li, L.; Barrett, TA "Myo-inositol reduces β-catenin activation in colitis." World journal of gastroenterology 23, 28 (2017): 5115-5126. [PubMed Link] | [ Full text ]
Cohran, V.; Managlia, E.; Bradford, EM ; Goretsky, T.; Li, T.; Katzman, RB ; Cheresh, P.; Brown, JB ; Hawkins, J.; Liu, SXL ; De Plaen, IG ; Weitkamp, JH ; Helmrath, M.; Zhang, Z.; Barrett, TA "Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection." The American journal of pathology 186, 7 (2016): 1837-1846. [PubMed Link] | [ Full text ]
Goretsky, T.; Bradford, EM ; Ryu, H ; Tahir, M.; Moyer, MP ; Gao, T.; Li, L.; Barrett, TA "A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer." The Journal of biological chemistry 291, 8 (2016): 4166-77. [PubMed Link] | [ Full text ]
Gounaris, E.; Ishihara, Y.; Shrivastrav, M.; Bentrem, D.; Barrett, TA "Near-Infrared Fluorescence Endoscopy to Detect Dysplastic Lesions in the Mouse Colon." Methods in molecular biology (Clifton, N.J.) 1422, (2016): 137-47. [PubMed Link] | [ Full text ]
Wen, YA ; Li, X.; Goretsky, T.; Weiss, HL ; Barrett, TA ; Gao, T. "Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis." Biochimica et biophysica acta 1852, 10 Pt A (2015): 2013-23. [PubMed Link] | [ Full text ]
Mathew, JM ; Tryphonopoulos, P.; DeFaria, W.; Ruiz, P.; Miller, J.; Barrett, TA ; Tzakis, AG ; Kato, T. "Role of innate and acquired immune mechanisms in clinical intestinal transplant rejection." Transplantation 99, 6 (2015): 1273-81. [PubMed Link] | [ Full text ]
Wang, Y.; Liu, X.; Pijut, SS ; Li, J.; Horn, J.; Bradford, EM ; Leggas, M.; Barrett, TA ; Graf, GA "The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination." Journal of lipid research 56, 4 (2015): 810-20. [PubMed Link] | [ Full text ]
Managlia, E.; Katzman, RB ; Brown, JB ; Barrett, TA "Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells." Inflammatory bowel diseases 19, 10 (2013): 2051-60. [PubMed Link] |
Gounaris, E.; Martin, J.; Ishihara, Y.; Khan, MW ; Lee, G.; Sinh, P.; Chen, EZ ; Angarone, M.; Weissleder, R.; Khazaie, K.; Barrett, TA "Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis." Inflammatory bowel diseases 19, 7 (2013): 1339-45. [PubMed Link] |
Barrett, TA "Developmental biology. Intestinal wound healing requires a Wnt balancing act." Science (New York, N.Y.) 338, 6103 (2012): 51-2. [PubMed Link] | [ Full text ]
Goretsky, T.; Dirisina, R.; Sinh, P.; Mittal, N.; Managlia, E.; Williams, DB ; Posca, D.; Ryu, H ; Katzman, RB ; Barrett, TA "p53 mediates TNF-induced epithelial cell apoptosis in IBD." The American journal of pathology 181, 4 (2012): 1306-15. [PubMed Link] | [ Full text ]
Dirisina, R.; Katzman, RB ; Goretsky, T.; Managlia, E.; Mittal, N.; Williams, DB ; Qiu, W.; Yu, J.; Chandel, NS ; Zhang, L.; Barrett, TA "p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis." Gastroenterology 141, 3 (2011): 1036-45. [PubMed Link] | [ Full text ]
Lee, G.; Goretsky, T.; Managlia, E.; Dirisina, R.; Singh, AP ; Brown, JB ; May, R.; Yang, GY ; Ragheb, JW ; Evers, BM ; Weber, CR ; Turner, JR ; He, XC ; Katzman, RB ; Li, L.; Barrett, TA "Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis." Gastroenterology 139, 3 (2010): 869-81, 881.e1-9. [PubMed Link] | [ Full text ]
Tang, Y.; Clayburgh, DR ; Mittal, N.; Goretsky, T.; Dirisina, R.; Zhang, Z.; Kron, M.; Ivancic, D.; Katzman, RB ; Grimm, G.; Lee, G.; Fryer, J.; Nusrat, A.; Turner, JR ; Barrett, TA "Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation." The American journal of pathology 176, 1 (2010): 158-67. [PubMed Link] | [ Full text ]
Brown, JB ; Lee, G.; Managlia, E.; Grimm, GR ; Dirisina, R.; Goretsky, T.; Cheresh, P.; Blatner, NR ; Khazaie, K.; Yang, GY ; Li, L.; Barrett, TA "Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis." Gastroenterology 138, 2 (2010): 595-605, 605.e1-3. [PubMed Link] | [ Full text ]
He, XC ; Yin, T.; Grindley, JC ; Tian, Q.; Sato, T.; Tao, WA ; Dirisina, R.; Porter-Westpfahl, KS ; Hembree, M.; Johnson, T.; Wiedemann, LM ; Barrett, TA ; Hood, L.; Wu, H.; Li, L. "PTEN-deficient intestinal stem cells initiate intestinal polyposis." Nature genetics 39, 2 (2007): 189-98. [PubMed Link] | [ Full text ]
Sanft, T.; Barrett, TA ; Barr, WG ; Jones, MP "Henoch-Schönlein Purpura Presenting as Terminal Ileitis: Case Report and Review of Unusual Causes of Ileitis." Gastroenterology & hepatology 2, 5 (2006): 375-378. [PubMed Link] |
Zhang, Z.; Kaptanoglu, L.; Tang, Y.; Ivancic, D.; Rao, SM ; Luster, A.; Barrett, TA ; Fryer, J. "IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection." Gastroenterology 126, 3 (2004): 809-18. [PubMed Link] | [ Full text ]
Hurst, SD ; Barrett, TA "T-cell responses to enteric antigens." Seminars in gastrointestinal disease 7, 3 (1996): 118-23. [PubMed Link] |