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Terrence A. Barrett, MD
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  • Connect
  • About
  • Education
  • Publications
  • t.barrett@uky.edu
  • Clinic : (859) 323-0079; Academic Office: (859) 323-4887
  • MN649 WM R WILLARD MED ED BLDG
Position(s): 
Professor
Division Chief
Affiliation(s): 
Internal Medicine
Other Affiliation(s): 
Internal Medicine - Digestive Health
Microbiology, Immunology & Molecular Genetics - Adjunct Faculty
Bio / Education: 
University of Illinois, Chicago, ILMD06/1983Medicine
Rush Presbyterian St. Luke's Hospital, Chicago, ILResidency06/1986Internal Medicine
University of Chicago, Chicago, ILFellowship06/1990Gastroenterology
PubMed Publications: 
  • Wechsler, J.B.;Szabo, A.;Hsu, C.L.;Krier-Burris, R.A.;Schroeder, H.A.;Wang, M.Y.;Carter, R.G.;Velez, T.E.;Aguiniga, L.M.;Brown, J.B.;Miller, M.L.;Wershil, B.K.;Barrett, T.A.;Bryce, P.J. "Histamine drives severity of innate inflammation via histamine 4 receptor in murine experimental colitis." Mucosal immunology 11, 3 (2018): 861-870. [PubMed Link] | [ Full text ]
  • Goretsky, T.;Bradford, E.M.;Ye, Q.;Lamping, O.F.;Vanagunas, T.;Moyer, M.P.;Keller, P.C.;Sinh, P.;Llovet, J.M.;Gao, T.;She, Q.B.;Li, L.;Barrett, T.A. "Beta-catenin cleavage enhances transcriptional activation." Scientific reports 8, 1 (2018): 671. [PubMed Link] | [ Full text ]
  • Davoudi, Z.;Peroutka-Bigus, N.;Bellaire, B.;Wannemuehler, M.;Barrett, T.A.;Narasimhan, B.;Wang, Q. "Intestinal organoids containing poly(lactic-co-glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases." Journal of biomedical materials research. Part A 106, 4 (2018): 876-886. [PubMed Link] | [ Full text ]
  • Cai, T.;Qi, Y.;Jergens, A.;Wannemuehler, M.;Barrett, T.A.;Wang, Q. "Effects of six common dietary nutrients on murine intestinal organoid growth." PloS one 13, 2 (2018): e0191517. [PubMed Link] | [ Full text ]
  • Bradford, E.M.;Ryu, S.H.;Singh, A.P.;Lee, G.;Goretsky, T.;Sinh, P.;Williams, D.B.;Cloud, A.L.;Gounaris, E.;Patel, V.;Lamping, O.F.;Lynch, E.B.;Moyer, M.P.;De Plaen, I.G.;Shealy, D.J.;Yang, G.Y.;Barrett, T.A. "Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease." Journal of immunology (Baltimore, Md. : 1950) 199, 5 (2017): 1886-1897. [PubMed Link] | [ Full text ]
  • Feng, Y.;Demehri, F.R.;Xiao, W.;Tsai, Y.H.;Jones, J.C.;Brindley, C.D.;Threadgill, D.W.;Holst, J.J.;Hartmann, B.;Barrett, T.A.;Teitelbaum, D.H.;Dempsey, P.J. "Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition." Cellular and molecular gastroenterology and hepatology 3, 3 (2017): 447-468. [PubMed Link] | [ Full text ]
  • Pauly, N.J.;Michailidis, L.;Kindred, M.G.;Flomenhoft, D.;Lofwall, M.R.;Walsh, S.L.;Talbert, J.C.;Barrett, T.A. "Predictors of Chronic Opioid Use in Newly Diagnosed Crohn's Disease." Inflammatory bowel diseases 23, 6 (2017): 1004-1010. [PubMed Link] | [ Full text ]
  • Bradford, E.M.;Thompson, C.A.;Goretsky, T.;Yang, G.Y.;Rodriguez, L.M.;Li, L.;Barrett, T.A. "Myo-inositol reduces β-catenin activation in colitis." World journal of gastroenterology 23, 28 (2017): 5115-5126. [PubMed Link] | [ Full text ]
  • Cohran, V.;Managlia, E.;Bradford, E.M.;Goretsky, T.;Li, T.;Katzman, R.B.;Cheresh, P.;Brown, J.B.;Hawkins, J.;Liu, S.X.L.;De Plaen, I.G.;Weitkamp, J.H.;Helmrath, M.;Zhang, Z.;Barrett, T.A. "Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection." The American journal of pathology 186, 7 (2016): 1837-1846. [PubMed Link] | [ Full text ]
  • Goretsky, T.;Bradford, E.M.;Yu, H.R.;Tahir, M.;Moyer, M.P.;Gao, T.;Li, L.;Barrett, T.A. "A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer." The Journal of biological chemistry 291, 8 (2016): 4166-77. [PubMed Link] | [ Full text ]
  • Gounaris, E.;Ishihara, Y.;Shrivastrav, M.;Bentrem, D.;Barrett, T.A. "Near-Infrared Fluorescence Endoscopy to Detect Dysplastic Lesions in the Mouse Colon." Methods in molecular biology (Clifton, N.J.) 1422, (2016): 137-47. [PubMed Link] | [ Full text ]
  • Wen, Y.A.;Li, X.;Goretsky, T.;Weiss, H.L.;Barrett, T.A.;Gao, T. "Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis." Biochimica et biophysica acta 1852, 10 Pt A (2015): 2013-23. [PubMed Link] | [ Full text ]
  • Mathew, J.M.;Tryphonopoulos, P.;DeFaria, W.;Ruiz, P.;Miller, J.;Barrett, T.A.;Tzakis, A.G.;Kato, T. "Role of innate and acquired immune mechanisms in clinical intestinal transplant rejection." Transplantation 99, 6 (2015): 1273-81. [PubMed Link] | [ Full text ]
  • Wang, Y.;Liu, X.;Pijut, S.S.;Li, J.;Horn, J.;Bradford, E.M.;Leggas, M.;Barrett, T.A.;Graf, G.A. "The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination." Journal of lipid research 56, 4 (2015): 810-20. [PubMed Link] | [ Full text ]
  • Managlia, E.;Katzman, R.B.;Brown, J.B.;Barrett, T.A. "Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells." Inflammatory bowel diseases 19, 10 (2013): 2051-60. [PubMed Link] |
  • Gounaris, E.;Martin, J.;Ishihara, Y.;Khan, M.W.;Lee, G.;Sinh, P.;Chen, E.Z.;Angarone, M.;Weissleder, R.;Khazaie, K.;Barrett, T.A. "Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis." Inflammatory bowel diseases 19, 7 (2013): 1339-45. [PubMed Link] |
  • Barrett, T.A. "Developmental biology. Intestinal wound healing requires a Wnt balancing act." Science (New York, N.Y.) 338, 6103 (2012): 51-2. [PubMed Link] | [ Full text ]
  • Goretsky, T.;Dirisina, R.;Sinh, P.;Mittal, N.;Managlia, E.;Williams, D.B.;Posca, D.;Yu, H.R.;Katzman, R.B.;Barrett, T.A. "p53 mediates TNF-induced epithelial cell apoptosis in IBD." The American journal of pathology 181, 4 (2012): 1306-15. [PubMed Link] | [ Full text ]
  • Dirisina, R.;Katzman, R.B.;Goretsky, T.;Managlia, E.;Mittal, N.;Williams, D.B.;Qiu, W.;Yu, J.;Chandel, N.S.;Zhang, L.;Barrett, T.A. "p53 and PUMA independently regulate apoptosis of intestinal epithelial cells in patients and mice with colitis." Gastroenterology 141, 3 (2011): 1036-45. [PubMed Link] | [ Full text ]
  • Lee, G.;Goretsky, T.;Managlia, E.;Dirisina, R.;Singh, A.P.;Brown, J.B.;May, R.;Yang, G.Y.;Ragheb, J.W.;Evers, B.M.;Weber, C.R.;Turner, J.R.;Che, X.;Katzman, R.B.;Li, L.;Barrett, T.A. "Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis." Gastroenterology 139, 3 (2010): 869-81, 881.e1-9. [PubMed Link] | [ Full text ]
  • Tang, Y.;Clayburgh, D.R.;Mittal, N.;Goretsky, T.;Dirisina, R.;Zhang, Z.;Kron, M.;Ivancic, D.;Katzman, R.B.;Grimm, G.;Lee, G.;Fryer, J.;Nusrat, A.;Turner, J.R.;Barrett, T.A. "Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation." The American journal of pathology 176, 1 (2010): 158-67. [PubMed Link] | [ Full text ]
  • Brown, J.B.;Lee, G.;Managlia, E.;Grimm, G.R.;Dirisina, R.;Goretsky, T.;Cheresh, P.;Blatner, N.R.;Khazaie, K.;Yang, G.Y.;Li, L.;Barrett, T.A. "Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis." Gastroenterology 138, 2 (2010): 595-605, 605.e1-3. [PubMed Link] | [ Full text ]
  • Che, X.;Yin, T.;Grindley, J.C.;Tian, Q.;Sato, T.;Tao, W.A.;Dirisina, R.;Porter-Westpfahl, K.S.;Hembree, M.;Johnson, T.;Wiedemann, L.M.;Barrett, T.A.;Hood, L.;Wu, H.;Li, L. "PTEN-deficient intestinal stem cells initiate intestinal polyposis." Nature genetics 39, 2 (2007): 189-98. [PubMed Link] | [ Full text ]
  • Sanft, T.;Barrett, T.A.;Barr, W.G.;Jones, M.P. "Henoch-Schönlein Purpura Presenting as Terminal Ileitis: Case Report and Review of Unusual Causes of Ileitis." Gastroenterology & hepatology 2, 5 (2006): 375-378. [PubMed Link] |
  • Zhang, Z.;Kaptanoglu, L.;Tang, Y.;Ivancic, D.;Rao, S.M.;Luster, A.;Barrett, T.A.;Fryer, J. "IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection." Gastroenterology 126, 3 (2004): 809-18. [PubMed Link] | [ Full text ]
  • Hurst, S.D.;Barrett, T.A. "T-cell responses to enteric antigens." Seminars in gastrointestinal disease 7, 3 (1996): 118-23. [PubMed Link] |
Chairman’s Office: (859) 257-5116
Clinical Questions: (859) 257-1000
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