Treatments Against RA and Effect on FDG-PET/CT: the TARGET Trial 

Rheumatoid arthritis (RA) is a chronic inflammatory disease. People with RA are at a high risk for strokes, heart attacks, heart failure, and related diseases which all together are called cardiovascular diseases (CVD). CVD risk is higher in RA patients compared to people of the same age and gender who do not have RA. We believe the increased CVD risk in RA is likely due to higher vascular inflammation. In partnership with physicians at Brigham and Women's Hospital, the TARGET trial is being done to find out the link between RA and vascular inflammation, learn whether increased systemic inflammation causes CVD, and figure out which treatment approaches have a better effect on vascular inflammation and controlling RA disease activity.